TOPIC: Infections, Complications, Risks of PMMA?

I'm sure this question has been addressed at some point but it bothers my a little that PMMA Girth enhancement isn't more widespread. I understand why its use is restricted in the US, but why are there no doctors (that I know of) doing this in Europe, where many different brands of PMMA are legal?

@smartman

Well done! An apples to apples comparison is what we are all after! Being aware of possible or foreseeable complications is always to our benefit as well as potential remedies. Thanks for the contribution!!!

@mikehok - that is a really great question. Since we know that antimitotics like 5FU are used to treat PMMA granulomas and reduce lumps it is reasonable to assume that the newer more powerful chemo antimotic products delivered systemically could deteriorate the encapsulating tissue.

supa wrote: ... I would not be so sure of that. The choice of placing the product very near the ophthalmic artery can be a poor one. The material is indeed not supposed to move from the location where it has been injected but if it was administered very near the artery it is conceivable that some of it has reached it during the procedure;...

Are you saying one should not do work in the Glabella? Once you work in that area you are going to be near a blood vessel. All the arteries in that region have significant anastomoses. Look again at the Dr C. video, was he near a blood vessel? The technique is fine, the area is risky. A lot of well-respected surgeons will not put any type of filler in this area.

supa wrote: ...The material is indeed not supposed to move from the location where it has been injected but if it was administered very near the artery it is conceivable that some of it has reached it during the procedure;....

Thank you for bringing this discussion back to the central point. The Caldellas Newplastic study of 21 patients showed Macrophage phagocytosis in all 21 patients. If the PMMA particles are small enough to be eaten by a Macrophage they will move!

supa wrote: ...Can I ask you again: would you consider bioplasty to the penis using Artefill? Not that you would actually go now and have it. Rather, if you feel that it is a sound procedure to seriously consider. Or, on the contrary, if you would also equally and firmly reject it, at this point in time;...

If one must have PE then IMO Artefill, if it performs in the penis like it does in the face in the 36 month interim study, may be sounder than all the other PE alternatives. Having said that we should be clear that for every 10 people that have the procedure, at the 5 year mark it is likely that 1 or 2 will have some adverse effect including lumpiness, swelling and redness, lesions, treatable granulomas, and granulomas that will need to be surgically removed. We do not know how the higher volumes (10x) required in the penis will change the risks.

HoddleI can certainly see what you are saying. Since the shaft skin is independent of the fascia, and the PMMA is placed below the fascia, logically if a granuloma did develop, it should not affect the shaft skin.

Yes, but a useless one that didn't address the question.

Thanks for the links Supa! Looking forward to finding some time to thoroughly review these articles, the "G" word is of considerable importance to many on this forum that's for sure!

Re: The horror picture portraying a disfigured face.

It would seem down to poor technique; I read in the article:

" ... the PMMA microspheres were injected very near branches of the ophthalmic artery, which caused embolism in the vassel.2 We also know of complications also associated with the use of an autologous graft when the injection is carried out in the glabellar region.6
In this report, the complication mechanism was similar. PMMA was injected in the nasogenian groove, or directly into the right facial artery, or very near it. There was arterial embolism: right angular artery, right superior and inferior labial coronal arteries".

Not the product is to blame then, if we take the excerpt literally, but rather the location where it was injected.

Thoughts?

P.S.
I truly and deeply think that challenging info/doc/research documents are absolutely crucial for our long journey to a thorough assessment of PMMA. Thank you eqstudent for your contributions. Please, keep it up.

At the same time I did resent your patronizing attitude when replying to smartman. He has brought wealth of technical info to this forum on top of sharing his long-term experience with us: both extremely valuable assets.
I personally would welcome more imperturbability when objecting to points of view of a fellow forum brother. Rest assured that I still would avidily read your inputs. We are all here to learn and contribute. Btw, I confess, I do ignore the basic facts of biology, so I am happy to know more.

Final question: you "will not be using Artefill for chin augmentation" ... would you use Artefill for penis Girth augmentation?

supa wrote: Does anyone know the overall granuloma complication rate on Dr C.'s total number of patients (wrt PMMA to the penis)? After all, he has started PE via PMMA some five years ago.

I think I read he's only had one granuloma when injecting below the fascia on any part of the body. He doesn't think granulomas occur when injected below the fascia and this is why Artefill studies, which inject into the skin itself aren't really that relevant to us.

@hoddle

did u get a response on RealSelf?

@eqstudent

Thank you for your insightful research into unexplored territory. We all assume the associated risk when undertaking a new medical procedure. FBG can occur from a plethora of injectables in various parts of the body. Sometimes, our bodies just don't agree with our decisions. Good advice to all considering augmentation with PMMA. The pathology is similar, however, there are many variables as you well know. Some may experience serious adverse reactions long term; others may not have any. Some will be treatable. Some will require surgery. It is unwise to recommend such a procedure without acknowledging ALL associated risks. Thanks for shedding some light on this subject. Especially to some of the "young guns" that come on board and (due to their youth/ignorance) hop on board the PMMA proverbial wagon.

Well if your question is true, the evidence is when you have the problem. You'll know it when you have it & then i'll buy you a beer!

Could one of you guys refresh us on the Cadellus stuff? This was in the 180 page thread if I recall. I think we came to conclusion risk 1) Necrosis: not happending "later" happens early on due to needle, not just PMMA but injection related2) migration: PMMA biocompatible not going to cause cancer, your system can respond3) absorption: not discussed, not a lot of evidence4) granuloma: down the line, Kenalog shot.Lemperle said straight out biggest risk he sees is assymetry/aesthetics. It would be no suprise to see some people unhappy, including possibly me! Touch up sessions available for this. Changing your unit is a big risk, and once you change it there is no going back.

@hoddle10

Nobody is to blame or is "at fault". You've done a great deal to help others. Surgical as well as non-surgical augmentation of one's "pride and joy" is not something that should ever be entered into lightly. I implore all considering PMMA or any other augmentative procedure to explore all possible methods/procedures and the corresponding risks. Each procedure has pros and cons and associated risks. I would advise anyone under the age of 25 to use this forum as an education center. SO, EP, Supa, EQ, smartman, myself and others have touched on this topic before. That being said... I personally see PMMA as the best choice/alternative for Girth enhancement at this point in time. Who knows, in six months, PMMA could be considered outdated and a barbaric attempt of the past to enlarge one's penis. To our younger members/guests, realize that the ramifications of surgery are real. Complications (though rare) DO occur. I'd hate to be in my teens/twenties and lose the use of my penis; the joy that it brings both myself and my respective partner. It is catastrophic; physically, emotionally and mentally. I know. I suffered from peyronie's for 15 long years. Think about it people. That is all.

@eq - (( @smartman - You are all over the map, I am done with this. Good Luck! ))
Why have you said that?? The most important topic we have discussed before was:-
Was there any patient in the literature complaining of a serious complication (e.g. DISTANT ORGAN) from Newplastic which can be due to migration of the SMALL beads , correct ???
These studies you have mentioned above were NOT the answer for that Q. , so if you think it was the answer , I am sorry you might be right.
But the most important thing I have found is the presence of <1% of smaller beads in Artefill , if that is true , and as we were discussing before that the Newplastic has small beads too , so why did the FDA give the approval for Artefill in 2006 ??
So it is either the FDA has missed that serious complication of the possibility of migration of the small beads ---> liver or lung failure . It will be a big mistake if it was true .
Or they did know about the presence of <1% of small beads (< 20 micron) in Artefill , but they were 100% sure there will be no distant organ complication from these small beads (i.e. small beads doesn't cause any serious complication).
So eqstudent I dont know who is all over the map ?? I will let the others to decide about that . May be the 3 minutes were too short for the research.
Would you still do the chin augmentation with Artefill by your doctor ??